"G.B." <nonono@nospam.invalid.com> wrote in message
news:4153484e$0$186$edfadb0f@dread11.news.tele.dk...
> Er du enig med det, de skriver? Til benefice for resten af gruppen skal
> jeg her bringe en cut'n'paste synopsis:
Er DU enig med forskerne i deres konklusioner?
Til benefice for gruppen bringer jeg her en cut'n'paste synopsis:
***
<citat>
Int Immunopharmacol. 2004 Mar;4(3):411-8.
Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation.
Sampedro MC, Artola RL, Murature M, Murature D, Ditamo Y, Roth GA, Kivatinitz S.
Departamento de Quimica Biologica-CIQUIBIC, Facultad Ciencias Quimicas,
Universidad Nacional de Cordoba, Cuidad Universitaria, C5000GYA-Cordoba 5016,
Argentina.
In this study, we tested the antiproliferative effects of mannan from Aloe
saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral
cell lines. Employing flow cytometry, it could be determined that mannan
inhibits the proliferative response in normal and tumoral cells. Mannan affects
the expression of CD3(+) SpMC indicating that mannan inhibits mainly T
lymphocyte proliferative response. Also in SpMC cultured with or without mitogen
mannan produces an increase of an activation marker (CD25). On C1498 cell line,
mannan reduces CD3 expression and abolishes the CD25 expression. In conclusion,
mannan has a dual beneficial effect when applied to normal and tumoral cells at
the same time by inhibiting the activation of cancer cells and improving that of
normal ones.
PMID: 15037218 [PubMed - in process]
</citat slut>
***
<citat>
Oncol Rep. 2004 Jan;11(1):213-7.
Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation
of an adherent variant cell line of Merkel cell carcinoma.
Fenig E, Nordenberg J, Beery E, Sulkes J, Wasserman L.
Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva
49100, Israel. efenig@clalit.org.il
Merkel cell carcinoma (MCC) has only limited sensitivity to chemotherapeutic
agents. The aim of the study was to determine if members of the anthraquinone
family could be used as adjuncts to increase the growth inhibiting effect of
anticancer agents in MCC. An adherent variant of MCC was derived from a
previously established MCC cell line suspension. Cells were characterized by
immunocytochemical methods using specific antibodies against epithelial (low
molecular weight cytokeratins and cytokeratin 20) and neuroendocrine
(neuron-specific enolase, neurofilament protein, chromogranin A and
synaptophysin) antigens. Emodin and aloe-emodin, members of the anthraquinone
family, inhibited proliferation of the adherent MCC cells, with a slight
advantage of aloe-emodin over emodin. Aloin had no effect on cell proliferation.
The chemotherapeutic agents, cis-platinol (abiplastin), doxorubicin
(adriablastin), and 5-fluorouracil, and the tyrosine kinase inhibitor STI 571,
all independently inhibited the proliferation of adherent MCC cells. The
addition of aloe-emodin potentiated their inhibitory effect, especially when low
concentrations of the anticancer compounds were used. The antiproliferative
action of STI 571 may be associated with the presence of anti-c-kit antibodies.
The combined use of anticancer agents, especially at low concentrations, and
aloe-emodin may be considered a preferable means for treating MCC.
PMID: 14654928 [PubMed - indexed for MEDLINE]
</citat slut>
***
<citat>
Trop Med Int Health. 1996 Aug;1(4):505-9.
Management of psoriasis with Aloe vera extract in a hydrophilic cream: a
placebo-controlled, double-blind study.
Syed TA, Ahmad SA, Holt AH, Ahmad SA, Ahmad SH, Afzal M.
Department of Clinical Physiology, Malmo University Hospital, Sweden.
The purpose of this double-blind, placebo-controlled study was to evaluate the
clinical efficacy and tolerability of topical Aloe vera extract 0.5% in a
hydrophilic cream to cure patients with psoriasis vulgaris. Sixty patients
(36M/24F) aged 18-50 years (mean 25.6) with slight to moderate chronic
plaque-type psoriasis and PASI (Psoriasis Area and Severity Index) scores
between 4.8 and 16.7 (mean 9.3) were enrolled and randomized to two parallel
groups. The mean duration of the disease prior to enrollment was 8.5 years
(range 1-21). Patients were provided with a precoded 100g tube, placebo or
active (with 0.5% Aloe vera extract), and they self-administered trial
medication topically (without occlusion) at home 3 times daily for 5 consecutive
days per week (maximum 4 weeks active treatment). Patients were examined on a
weekly basis and those showing a progressive reduction of lesions, desquamation
followed by decreased erythema, infiltration and lowered PASI score were
considered healed. The study was scheduled for 16 weeks with 12 months of
follow-up on a monthly basis. The treatment was well tolerated by all the
patients, with no adverse drug-related symptoms and no dropouts. By the end of
the study, the Aloe vera extract cream had cured 25/30 patients (83.3%) compared
to the placebo cure rate of 2/30 (6.6%) (P < 0.001) resulting in significant
clearing of the psoriatic plaques (328/396 (82.8%) vs placebo 28/366 (7.7%), P <
0.001) and a decreased PASI score to a mean of 2.2. The findings of this study
suggest that topically applied Aloe vera extract 0.5% in a hydrophilic cream is
more effective than placebo, and has not shown toxic or any other objective
side-effects. Therefore, the regimen can be considered a safe and alternative
treatment to cure patients suffering from psoriasis.
Publication Types:
a.. Clinical Trial
b.. Randomized Controlled Trial
PMID: 8765459 [PubMed - indexed for MEDLINE]
</citat slut>
--
Timo Jensen. Aloe-Shop Danmark
http://www.mlm-life.com/
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